80 mg / ml, solution for injection for horses, cattle, pigs, sheep, goats, dogs and cats, used in cardiac disorders and cardiovascular failure

The content of the active substance and other substances
1 ml of the product contains:

The active substance:
Caffeine 80 mg

Sodium benzoate (E211) 120 mg

Therapeutic indications
Heart failure and cardiovascular failure in the course of infectious diseases in non-life-threatening conditions.

Do not use in the case of acute heart failure, myocardial hypoxia.

Side effects
Local reactions related to the irritating effect of the drug may occur when caffeine is administered subcutaneously.

After intravenous administration of caffeine, restlessness, agitation, increased heart rate and arrhythmia may occur. An increase in respiratory rate is also observed.

Intravenous administration of caffeine in genetically sensitive piglets to stress causes typical clinical symptoms of the stress factor, which is manifested by anxiety, motor activity, sounds, increased heart rate and increased number of breaths, as well as an increase in creatine phosphokinase activity (45 minutes after caffeine administration). There may also be disturbances in the functions of the gastrointestinal tract as a result of an increase in the secretion of gastric glands.

In animals with known epilepsy, convulsions may occur after intravenous administration of caffeine.

About the occurrence of side effects after administering this product or observing any disturbing symptoms not listed in the leaflet (including symptoms in humans as a result of contact with the drug), please notify the competent veterinarian, the responsible entity or the Office for Registration of Medicinal Products, Medical Devices and Biocidal Products. The application form should be downloaded from the website (Department of Veterinary Medicinal Products).

Dosage for each species, route and method of administration
The product is administered subcutaneously, intramuscularly or intravenously in the following doses:

horses, cattle 5 – 20 ml
pigs, sheep, goats 1.5 – 7.5 ml
dogs 0.25 – 0.75 ml
cats 0.05 – 0.5 ml
When determining the dose, the clinical condition of the animal, its weight, the route of administration and the individual sensitivity to caffeine should be taken into account.

When administered subcutaneously or intramuscularly, the effect appears after 15-30 minutes, while after intravenous administration it takes effect immediately. In justified cases, the dose of the drug may be repeated after 6-8 hours.

Recommendations for correct administration

Grace period

Edible tissues:
Horses, cattle, pigs, sheep, goats: zero days

Cattle, sheep, goats: zero days

Dogs, cats: not applicable

Special precautions for storage
Keep out of the sight and reach of children.
Store below 25 ° C. Protect from light. Do not freeze.
Do not use this veterinary medicinal product after the expiry date stated on the label.
Shelf life after first opening the immediate packaging: 28 days.

Special warnings

Special precautions for use in animals:
In patients with known epilepsy, caffeine should only be used after weighing the benefits against risks. In the event of adverse central nervous system symptoms, the administration of the drug should be discontinued immediately and anticonvulsant therapy should be instituted.

Special precautions to be taken by the person administering the veterinary medicinal product to animals:
Avoid direct contact with the product. In the event of accidental self-injection, immediately seek medical help and show the doctor the information leaflet or the packaging.
Caffeine may be life-threatening if consumed in a dose of 5-10 g. Severe poisoning has been observed after consuming caffeine in a dose of 1.0 g (15 mg / kg b.w.).

The safety of the veterinary medicinal product in the target species has not been established during pregnancy.
The product should only be used during pregnancy according to the benefit / risk assessment by the responsible veterinarian.

The safety of the veterinary medicinal product in the target species has not been established during lactation.
The product during lactation should only be used according to the benefit / risk assessment by the responsible veterinarian.

Interaction with other medicinal products and other forms of interaction:
Caffeine enhances the effect of digitalis preparations and beta-adrenomimetic drugs.
With the simultaneous use of methylxanthines and drugs from the beta-adrenomimetics group (adrenaline, isoprenaline, orciprenaline), the effects of both groups of drugs on the heart are potentiated, which is manifested by the occurrence of cardiac arrhythmia. The synergism of inotropic-positive effects of caffeine and cardiac glycosides was also found.

Overdose (symptoms, emergency procedures, antidotes):
Tachycardia or tachycardia with arrhythmias, drop in blood pressure, and restlessness may occur after caffeine overdose. Convulsions may occur at toxic doses. Moreover, an overdose of the product may lead to muscle stiffness and tremor, increased diuresis. Vomiting may occur in carnivores. In the event of an overdose of caffeine, the use of sodium pentobarbital is recommended.

Pharmaceutical Incompatibilities:
As no compatibility studies have been performed, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

Special precautions for the disposal of unused veterinary medicinal products or waste materials
Medicines should not be disposed of via wastewater or with household waste.
Ask your veterinarian about how to remove useless drugs. They will allow for better protection of the environment.

Period of validity
2 years

For animals only
To be dispensed with a prescription – Rp
To be administered under the supervision of a veterinarian.

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